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Multiple people suffered serious injuries, including several who are critically hurt, officials said.
The bus, carrying students from Farmingdale High School, rolled over and slid off Interstate 84.
New York Gov. Kathy Hochul said she’s been briefed on the accident.
“Personnel from the New York State Police and the Division of Homeland Security and Emergency Services are onsite to assist local emergency response teams,” Hochul said in a statement. “We are grateful for the first responders whose speedy action saved lives and we will continue to support them however necessary. Our hearts are with all who are impacted by this horrific situation.”
Farmingdale School District officials are also at the scene, the district said.
The school’s other five buses are now heading back to Farmingdale, but will make a stop on the way to give students the chance to meet with grief counselors, the district said.